The return flight will leave San Francisco at 8:48 a.m. and arrive in New Orleans at 3:03 p.m.
The addition comes amid a push to expand the airline's Bay Area footprint after Alaska Airlines acquired Virgin America, with 13 new nonstop flights to San Francisco International Airport and Mineta San Jose Airport, according to an Alaska Airlines press release. Alaska Airlines is now the fifth largest airline in the United States.
From San Francisco, Alaska will use the Virgin America fleet to fly to Philadelphia, New Orleans, Nashville, Indianapolis, Raleigh-Durham, Baltimore and Kona, Hawaii.
Most of the new routes will launch between late August and mid-October.More news: Russian Federation finally approved 'Beauty and the Beast, with a caveat
"We want to serve the biggest markets from the Bay Area", John Kirby, Alaska's vice president of capacity planning, told the San Francisco Business Times.
As an incentive to establish that service, the Indiana Economic Development Corp. offered United up to a $1.5 million annual backstop to cover any gap between the airline's revenue and a contracted minimum. On all of those routes except San Francisco-Philadelphia, United now has no competition, according to the website Flight Connections.
Virgin's network operated as a point-to-point system built around the San Francisco and Los Angeles metro areas.
The new Alaska Airlines routes will run between San Francisco and Albuquerque, New Mexico; Kansas City, Missouri; and Mexico City. Alaska has also announced plans to soon begin flights from San Jose to Newark and Burbank.