Entlitled, "Hitting Rock Bottom" the report details a dramatic rise in violence against Syrian children, as well as increasing risks of them being used as child soldiers.
The report said the 652 killed from conflict-related causes previous year represent a 20 percent increase over 2015.
The number of children killed in the war is the highest tally since UNICEF has verified the number of deaths in the conflict.
"I wanted to become a doctor but perhaps I won't become anything because our school was attacked", 6-year-old Ahmad is quoted as saying.
"Each and every child is scarred for life with horrific consequences on their health, well-being and future", Cappelaere said. Maiming and recruitment of children also rose sharply as violence across the country saw a drastic escalation. Children are recruited as fighters on the frontline, and in the a year ago increasingly as executioners, suicide bombers or prison guards.More news: UC beats UConn, will play for AAC title
Other aid groups, such as Save the Children, previously reported that millions of Syrian children could be living under a state of "toxic stress" due to the horrors of war, with fears that it could cause irreversible damage for an entire generation. More than 1.7 million children are out of school, and one in three schools have been either destroyed or repurposed to shelter displaced families or to serve the military. The report comes as the conflict in Syria enters its sixth year.
Education and medical treatment are becoming even more hard to access, and as a result, more families are turning to drastic measures for survival.
After six years of war, almost six million children now depend on humanitarian assistance, a 12-fold increase from 2012, the charity said.
"Over the past year in Syria, all parties involved have blocked vital aid supplies and millions have become poorer, hungrier and more isolated from assistance and from the world", said NRC's Mideast director, Carsten Hansen, according to The Associated Press. In a determination to learn, students and teachers have transformed basements into classrooms, sitting on the floor when furniture is not available.
UNICEF noted that it can not assess the "full scale of children's suffering" due to limited access to parts of Syria.