"We can confirm that Harry Kane sustained ligament damage to his right ankle during Sunday's FA Cup win against Millwall", Spurs posted on Twitter on Tuesday.
Kane missed 10 games in six weeks during the autumn with a similar injury.
He will miss Sunday's Premier League clash with Southampton and it was also thought he would miss the following ones against Burnley, Swansea, Watford and Bournemouth.
"Always we say they need to be professional, but they are only human and it is very tough to come in every day and it's very complicated". We are finding our best form now and the team is more solid.
Pochettino said: "We need to assess him day by day".More news: Cal coach Martin resigns to take Missouri job
Kane's injury comes at a crunch time of the season for Pochettino's side, who are now second in the Premier League in what is turning out to be a tight fight for a place in the top four. But before that Pochettino had said that 22-year-old had been looking much better in training, after publicly warning him to "do more". We lost Harry Kane for seven to eight weeks and one of the best performances was without him against Manchester City.
"Hugo has been playing in the Premier League and European competitions, and when you have a player like Michel Vorm, who is capable of playing at any club, he deserves to play in the semifinal - why not?" It was Ronald Koeman's men then that beat us 2-1 in the penultimate game of our season with two Steven Davis goals which led to Saints making their highest finish in 6th-place.
Spurs with Kane have been in fearsome form this term, sitting in impressive second in the Premier League with 33 points left to play for.
"Then we can say they are not flawless, that all will make mistakes, they are human". When you have a main striker like Harry Kane that scores goals and plays well, it's hard for your second or third striker or offensive player to take his place or have the possibility to play. That offensive spearhead will be hoping to make it an unlucky 13 for Spurs cos we have won 12 games in a row at the Lane.