Alex Oxlade-Chamberlain and Kieran Gibbs are doubts to face West Brom.
Champions League qualification is the priority for Wenger, who refused to discuss the protests against him before Arsenal beat Lincoln 5-0 in the FA Cup on Saturday.
"For us it's vital of course (to win at West Brom)".
While these three exits could be filed in the "understandable" folder, considering neither had been in their respective jobs for more than three years, news emerging on Tuesday that first-team coach Boro Primorac could be leaving to manage Turkish side Konyaspor at the end of the season certainly doesn't.
'Arsenal will have to defend very well at set plays and I think this could be a bit of a banana skin for Arsenal and I am going to go 2-2, which will be a nightmare result for their top-four hopes.
Wenger's 21-year spell as Gunners manager is now in serious question despite his success in north London, as he has failed to lead the club to a Premier League trophy since 2004.
They are in danger of losing three successive Premier League away games for the first time since October 2011. "I have talked enough about that", he said.More news: Oklahoma state senator charged with felony prostitution
But those aims are below the expectations of supporters who say Wenger has run out of ideas. So overall that's our targets.
"They have a big experience, they are well organised, physically very strong and very efficient on set-pieces", Wenger said.
Arsenal are Sky Bet's 8/11 favourites for the victory, with West Brom up against odds of 18/5 while the draw is priced at 14/5.
"On the rest, we are in the semi-finals of the FA Cup, we have an opportunity to do that as well".
Arsenal are preparing to travel to the Hawthorns to play West Bromwich Albion in their next match on Saturday. Although they remain in 8th position, they have lost their last two matches and that will fill Arsenal with confidence.
Alexis Sanchez has been involved in 26 Premier League goals this season (17 goals, nine assists) - more than any other player in the competition.