Ibuprofen linked to male infertility

Ibuprofen linked to male infertility

Ibuprofen, also known as an non-steroidal anti-inflammatory drug, has a negative impact on the testicles of young men, according to CNN. The scientist tested aspirin, Tylenol and ibuprofen.

Researchers came to this somewhat disturbing conclusion after splitting 31 male test subjects between the ages of 18 and 35 into two groups; they gave one group ibuprofen, and the other group a placebo.

The decreased ratio of testosterone to LH created a hormonal imbalance called "compensated hypogonadism" in the endocrine system, which regulates and controls hormones.

"We normally see this condition in elderly men, so it raises an alarm", study co-author Bernard Jégou of the French National Institute of Health and Medical Research, told The Guardian. Essentially testosterone levels were normal but the men in the ibuprofen group had higher amounts of luteinizing hormone, which stimulates testosterone production.

Richard Quinton, MD, from Newcastle University in England and the Society for Endocrinology, says: "This is a landmark study that elegantly combines clinical and basic research, at both tissue and cellular levels, to show that ibuprofen, a common over-the-counter painkiller, can reversibly hinder testosterone production by testicular cells". In the wake of this research, they focused their investigation on ibuprofen, which seemed to have the strongest effects. The treatment group received 2 doses of ibuprofen 600mg daily for 2 weeks before and 30 days after a single exercise season.

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'Several studies have shown mild analgesics exposure during foetal life is associated with anti-androgenic effects and congenital malformations. Long term, it can lead to a more serious condition called overt primary hypogonadism, which is characterized by low testosterone and libido, depressed mood and reduced muscle mass and strength.

The researchers also observed other hormonal disruptions at 14 and 44 days of ibuprofen consumption, suggesting wide-ranging consequences of hypogonadism.

A popular pain medication often popped by men who suffer minors aches and pains related to sports may be linked to infertility, according to a new study.

The study isn't the first to suggest that ibuprofen could be causing more harm than good. But researchers are concerned about long-term use among athletes.

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